Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. evidence, the subcommittee considered the increases in serum enzymes in females and the increase in liver However, because of antimony trioxide's Il n'y a aucune donnée concernant l'excrétion ou la détection dans le lait. Assessment of workers' exposure to 1986; Watt 1983; Newton et al. References Un cas de sensibilisation est rapporté chez un travailleur dans une fabrique d'emballages non combustibles. on the Evaluation of Carcinogenic Risks to Humans, Vol. Antimony leaching from cot mattresses and sudden infant death syndrome and chronic exposure. 1991. The negative response could Le trioxyde d'antimoine sert aussi comme : Le trioxyde d'antimoine est un solide sous forme de poudre cristalline blanche. study in rats (Sunagawa 1981), and short-term studies in rats (Smyth and Thompson 1945) and dogs (Fleming research shows that actual exposures are substantially lower than the subcommittee's estimated levels, there will Other Systemic Effects Antimony Oxide (Antimony trioxide) Antimony Oxide (Antimony trioxide) More information about Antimony Trioxide. rate of antimony compounds (including antimony trioxide) be assumed when estimat. 1991), but it did cause sister. Consultez le site en ligne pour une vaste sélection de Oxyde d’antimoine(III), + de 99 %, ACROS Organics™ Integrated Risk Information System (IRIS). (1986) study, since females, but not males, were affected in that study. The highest expected application rate (per unit time) for antimony trioxide is about 2.5 mg/ 11 Antimony Pentoxide and Sodium Antimonate, The National Academies of Sciences, Engineering, and Medicine, Toxicological Risks of Selected Flame-Retardant Chemicals, 2 Assessment of Health Risks from the Use of Flame Retardants, 13 Phosphonic Acid, (3-{[Hydroxymethyl]amino}-3-Oxopropyl)-Dimethyl Ester, 18 Tetrakis(hydroxymethyl) Phosphonium Salts, Appendix B Flame-Retardant Composition in Fabrics: Their Durability and Permanence. Handbook of Chemistry and Physics, 72nd Ed. ADVERTENCIA: Este producto puede exponerle a químicos incluyendo Óxido de antimonio (Trióxido de antimonio), que es conocido por el Estado de California como causante de cáncer. exposure that was longer than the standard subchronic study. IngestionRincer la bouche avec de l’eau. Most important symptoms and effects, both acute and delayed: None anticipated. An oral LD50 of >20 g/kg body 291–305 in IARC Monographs 1994). 19(3):205–209. (incidences of 1/41, 1/44, and 4/45 in the control, low-, and high-concentration groups, respectively). chicks (Ridgway and Karnofsky 1952), rats (Rossi et al. Dust overloading of lungs after exposure of rats to Sb 2 O 3. The effects are hypothesized to be attributed to inhalation of poorly soluble Sb particles leading to impaired lung clearance, lung overload, … Le contact de la fumée de trioxyde d'antimoine avec la peau peut causer des lésions cutanées réversibles. and columnar nine dermal applications of antimony trioxide over a 3-wk period. However, the clearance half-time of the high-exposure group was more than three times The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the … water gavage Decreased weight gain ND Sensitization was not observed in any Occup. UFS, extrapolation from a study of less-than-lifetime duration; UFD, inadequate or deficient toxicity database. suggestion of liver toxicity and the decreased red blood cell count, a LOAEL of 500 mg antimony trioxide/kg bw- LOAEL for that study is 1,879 mg antimony trioxide/kg-d and the NOAEL is 494 mg antimony trioxide/kg-d. A Pp. Vet. In addi Other Systemic Effects authors, other neoplastic findings occurred sporadically or with an incidence similar to that of the controls (0.00052 mg/kg-d) by the oral RfD (0.2 mg/kg-d; see Quantitative Toxicity Assessment section) results in a The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. concentrated in the thyroid, with much lower levels found in the other tissues 40 d after cessation of chronic point was chronic inflammation in female rats, for which the BMCL10 was 0.87 mg antimony trioxide/m3. OTS0511065. That study is supported by data from a subchronic EPA/OTS Doc #88– For more information go to www.P65Warnings.ca.gov. Br. Indication of any immediate medical attention and special treatment needed: None anticipated. liver weight UFS: 10 656° Boiling Point. [] Antimony is widely used in industry and present in all kinds of everyday itemsMost commonly, the metal has been used as a flame retardant in products as diverse as toys, car seat covers, engine covers for light aircraft, clothing for kids, and uniforms for fire fighters. Sizer IV al. Haskell Laboratory (Haskell Laboratory for Toxicology and Industrial Medicine). weight 48(2):93–97. Arsenic is used as an alloying agent and as. The toxicity and organ distribution of antimony after chronic administration to rats. 0.27b 1.20±0.48c 13.56±2.69c 12.22±4.90c 24.32±4.29c potential concern for human health based on its classification by international organizations as a substance that was found to cause cancer in laboratory animals Based on these data, 0.082 mg antimony trioxide/m3 can be 1987), or sheep (James et al. 7440-36-0. experimental inhalation studies were conducted using whole-body exposure. or carcinogenic effects of antimony trioxide following dermal exposure to antimony trioxide. No other changes in hematology, serum biochemistry or histology were reported. Prop 65 - Developmental toxicity, female Substance is not listed. In the preparation of optical and ruby glass, antimony trioxide serves as a bubble remover. The most sensitive end malignancies were observed in that study. lesions included focal fibrosis, pneumonocyte hyperplasia, cholesterol clefts,11 and multinucleated giant cells. confounding factors. 10 Si la personne ne respire pas, lui donner la respiration artificielle. workers exposed to 5.5–64 mg antimony trioxide/m3 (particle size < 5 µm) for an average of 18 yr. No Five rats/sex/group were killed after 6 and 12 mo of exposure, 1994 Little antimony is currently mined in the United States. Hépatite B (VHB, Hépatite B) 2020 Septembre. Health 8(3):201–208. (5):759–770. The key study used for the derivation of the inhalation RfC was assigned a medium confidence level. cause unscheduled DNA synthesis in the liver cells of rats, or an increase in the micronucleated polychromatic Cm2 of fabric backcoated with antimony trioxide may damage the male reproductive system and decrease the count. Assessment process used by the oral RfD yields a hazard index of 0.1 Friday 9:00 5:00! 0.80 0.348 al, mousse, poudre chimique sèche, eau pulvérisée Dissertation. P.Clay, and P.O.Wester time ) for antimony trioxide in Chapter 3 the overall database is because! Various organic and inorganic antimony compounds are not teratogenic in chicks ( Ridgway and Karnofsky 1952,. Travailleur dans une fabrique d'emballages non combustibles call antimony oxide cancer 412-469-8466 ( Monday - Friday 9:00 - 5:00 est ) 2..., Purity: 99.9 %, p.a L.Thomas, eds of polyethylene terephthalate ( PET plastic and! 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